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Diflucan 2 tablets daily for 4 weeks (3 mg), and the patient's symptoms resolved [10]. 3-month dosing study using 500 mg of an oral monotherapy regimen included 18 adults (5 men, 9 women) with acne vulgaris treated androgen depletion therapy and 2-3 cycles of isotretinoin (7.25 mg/day) followed by placebo. The study demonstrated favorable effects of a monoallergic monotherapy regimen on inflammatory markers, skin surface and lipids, sebum production in acne patients [13]. Three cycles of testosterone (100 mg) were given to 16 patients who had severe androgenic acne, and the testosterone-treated patients had significantly reduced inflammatory symptoms compared to the placebo group. However, a significant increase in sebum production was observed both treatment groups as opposed to normal control values [14]. Glandular Effects Studies have compared isotretinoin with its potential negative effects on sebaceous function since the first isotretinoin studies published in the 1970s [3]. A 4-week randomized, double-blinded, placebo-controlled study Buy orlistat uk of 15 females treated with high-dose isotretinoin (100,000 IU/day) found significant decreases buy diflucan online canada in the sebum-to-sebum ratio and sebum production (both of which are closely related to sebaceous gland function) compared placebo, a significant increase in sebum production, an the number of glandular papillae and sebaceous glands, significant improvements in secretio